Intereses de Investigación: Enfermedades y síndromes genéticos, Enfermedades de almacenamiento lisosomal
Link to: English versionn
Docencia (2024)
Facultad de Ciencias Médicas
Pregrado
- Embriología (Medicina- Coordinador)
- Embriología (Obstetricia)
Postgrado
- Diplomado USACH: Neurociencias: el cerebro humano en salud y enfermedad
Facultad de Química y Biología
Pregrado
- Química Fisiológica (Bioquímica)
- Genética (Bioquímica)
Postgrado
- Bases celulares de la neurociencia (Doctorado en Neurociencias USACH)
- Bases sistémicas de la neurociencia (Doctorado en Neurociencias USACH)
- Biología Celular y Molecular (Doctorado en Biotecnología USACH)
- Biomedicina (Doctorado en Biotecnología USACH)
Investigación
Direcciones de Tesis
- Estudiantes de pregrado (actuales y pasados): Diego Hernandez, Natalie Pino, Gabriel Astete, Jennifer Urbina, Tania Villalón
- Estudiantes de postgrado: Natalie Pino
Editorial
- Review Editor. Frontiers in Cell and Developmental Biology.
- Consulting Editor. Cytotechnology. Springer Publishing.
Publicaciones
- Milla L.A., Corral L., Rivera J., Zuñiga N., Pino G., Núnez-Parra A., and Cea-Del Rio C.
Neurodevelopment and early therapeutical interventions in FXS. Frontiers in Neuroscience (2023).
Aug 2;17:1213410
- Acuña-Castillo C., Barrera-Avalos C., Bachelet V.C., Milla L.A., Inostroza-
Molina A., Vidal M., Luraschi R., Vallejos-Vidal E., Mella-Torres A., Valdés D.,
Reyes-López F.E., Imarai M., Rojas P., Sandino A.M. Frontiers in Public Health (2023). Jul 10;11:1191377
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Cajas D., Guajardo E., Jara-Rosales S., Nuñez C., Vargas R., Carriel V., Campos A., Milla L., Orihuela P.A., Godoy-Guzmán C.
Molecules involved in the sperm-human uterine tube interaction: a histochemical and immunohistochemical approach.
European Journal of Histochemistry (2023) 67(2)
- Barrera-Avalos C., Briceño P., Valdés D., Imarai M., Leiva-Salcedo E., Rojo L.E.,
Milla L.A., Huidobro-Toro J.P., Robles-Planells C., Escobar A., Di Virgilio F.,
Morón G., Sauma D., Acuña-Castillo C. P2X7 receptor is essential for crossdressing
of bone marrow-derived dendritic cells. iScience (2021). Dec 17; 24(12):
103520
- del Campo A., Salamanca C., Fajardo A., Díaz-Castro F., Bustos C., Calfío C.,
Troncoso R., Pastene-Navarrete E.R., Acuña-Castillo C., Milla L.A., Villarroel
C.A, Cubillos F., Aranda M, Rojo L.E. Anthocyanins from Aristotelia chilensis
prevent Olanzapine-induced hepatic-lipid accumulation but not insulin resistance
in skeletal muscle cells. Molecules (2021). Oct 12;26(20):6149
- Barrera-Avalos C, Díaz X, Madrid B, Michelson SA, Robles-Planells C, Sánchez-
Guerrero G., Ahumada V., Mella-Torres A., Rojo L.E., Imarai M., Milla L.A.,
Leiva-Salcedo E., Murgas P., Fernández R., Escobar A., Acuña-Castillo C. In vivo
Antitumor Effect against Murine Cells of CT26 Colon Cancer and EL4 Lymphoma
by Autologous Whole Tumor Dead Cells. BioMed Research International
(2021) Feb 3;2021:1–16.
- Barrera-Avalos C., Mena J., López X, Cappelli C., Neira T., Imarai M., Fernández
R., Robles-Planells C., Rojo L.E., Milla L.A., Leiva-Salcedo E., Escobar A.,
Acuña-Castillo C. Adenosine triphosphate, Polymyxin B and B16 cells-derived
immunization induce anticancer response. Immunotherapy Jan 5 (2021).
- Robles-Planells C., Barrera-Avalos C., Rojo L.E., Spencer E., Cortez-SanMartin
M., Matiacevich S., Pávez J., Milla L.A., Navarro F.D., Martinez B.A., Bravo
F.J., Mella A., Huidobro-Toro J.P., Fernández R., Escobar A., Acuña-Castillo C.
Chitosan-based delivery of Avian Reovirus fusogenic protein p-10 Gene: in vitro
and in vivo studies towards a new vaccine against melanoma. BioMed Research International
1-11 (2020).
- Robles-Planells C., Sánchez G., Barrera-Avalos C., Matiacevich S., Rojo L.E.,
Pávez J., Salas-Huenuleo E., Kogan M.J., Escobar A., Milla L.A., Fernández
R., Imarai M., Spencer E., Huidobro-Toro J.P., Acuña-Castillo C. Chitosanbased
nanoparticles for intracellular delivery of ISAV fusion protein cDNA into
melanoma cells: A path to develop oncolytic anticancer therapies. Mediators of
Inflamation (2020) Apr 29: 8680692.
- Burgos H., Hernández A., Constandil L., Ríos M., Flores O., Puentes G., Hernández
K., Morgan C., Valladares L., Castillo A., Cofre C., Milla L.A., Sáez-Briones P.,
Barra R. Early postnatal environmental enrichment restores neurochemical and
functional plasticities of the cerebral cortex and improves learning performance
in hidden-prenatally-malnourished young-adult rats. Behav Brain Res (2019)
May 2;363:182-190.
- Villanueva A., Falcón P., Espinoza N., Solano L.R., Milla L.A., Hernández-
SanMiguel E., Torres V, Sánchez-Gómez P, Palma V. The Netrin-4/Neogenin-1
axis promotes neuroblastoma cell survival and migration. Oncotarget (2017) Feb
7;8(6):9767-9782
- Cao J., Ni J., Ma W., Shiu V., Milla L.A., Park S., Spletter M.L., Tang S.,
Zhang J., Wei Z., Kim S.K., and Scott M.P. Insight into insulin secretion from
transcriptome and genetic analysis of insulin-producing cells of Drosophila. Genetics
(2014) May;197(1):175-92.
- Milla L.A., Arros A., Espinoza N., Remke M., Kool M., Taylor M.D., Pfister
S.M., Wainwright B.J., Palma V. Neogenin1 is a Sonic Hedgehog target in medulloblastoma
and is necessary for cell cycle progression. International Journal of
Cancer (2014) Jan 1;134(1):21-31
- Milla L.A., González-Ramírez C.N., Palma V. Sonic Hedgehog in cancer stem
cells: a novel link with autophagy. Biological Research (2012);45(3):223-30.
- Milla L.A., Cortés C.R., Hödar H.Q., Oñate M., Cambiazo V., Burgess S.M.,
and Palma V. Yeast-based assay identifies novel Shh/Gli target genes in vertebrate
development. BMC Genomics (2012),13:2.
- Feijoo C.G., Oñate M., Milla L.A., and Palma V. Sonic Hedgehog (Shh)-Gli
signaling controls neural progenitor cell division in the developing tectum in zebrafish.
European Journal of Neuroscience (2011) Feb;33(4):589-98
- Cortés C.R., Milla L.A. and Palma V. Sonic hedgehog (SHH) regulates c-myc
expression in the developing brain: Direct or indirect link? Developmental Biology
(2009) Jul: 331(2):439
- Bergeron S., Milla L.A., Villegas R., Shena M., Burgess S.M., Allende M.L.,
Karlstrom R.O., and Palma V. Expression profiling identifies novel Hh/Gli regulated
genes in developing zebrafish embryos. Genomics (2008) Feb;91(2):165-177
- Tittarelli, A., Milla L., Vargas, F., Morales, A., Neupert, C., Meisel, L., Salvo,
H., Peñaloza, E., Muñoz, G., Corcuera, L. J. and Silva, H. Isolation and comparative
analysis of the wheat TaPT2 promoter: identification in silico of new
putative regulatory motifs conserved between monocots. Journal of
Experimental Botany (2007) Aug;58(10): 2573-2582
